The main objective of this research was strategic future research on the drivers of improving and developing digital-oriented human resource management strategies in digital businesses in the Islamic Republic of Iran. In terms of method, the present research is based on structural interaction matrix analysis with a strategic future research approach and in terms of purpose, it is of a developmental-applied type. The statistical population of this research consists of 31 experts, including university professors and human resource managers of digital businesses in the Islamic Republic of Iran, using a targeted method. The data of this research were collected through library studies, structured interviews, and a qualitative questionnaire rated from zero to three according to the structural interaction matrix and analyzed with the MICMAC statistical software. The findings of this research showed that the drivers of the transformation of traditional human resource structures with emerging technologies, the application of technology-oriented algorithms in the development of human resource strategies, and the resilience and agility of human resource operational processes are effective drivers. Also, the drivers of using digital systems in using and sharing human resource data, creating cross-sectoral knowledge-based interactions and networks with human resource management, developing interactive platforms to promote digital HR job skills, institutionalizing a technology-based culture in human resource strategies are influential drivers. Finally, the drivers of structured design of technology-based strategies for human resource management decision-making, integrating and integrating intelligent human resource management systems, and creating an integrated technology-based ecosystem in the human resource life cycle are independent drivers.